ʻO nā kumu o psoriasis e pili ana i ka genetic, immune, environmental a me nā mea ʻē aʻe, a ʻaʻole maopopo loa kona pathogenesis.
1. Nā kumu genetic
Ua hōʻike ʻia nā haʻawina he nui ke kuleana koʻikoʻi o nā genetic factor i ka pathogenesis o psoriasis. ʻO ka mōʻaukala ʻohana o ka maʻi he 10% a 23.8% o nā maʻi ma Kina a ma kahi o 30% ma nā ʻāina ʻē.He 2% ka nui o ka loaa ana o ke keiki me ka ma'i psoriasis, ina aole i loaa i kekahi makua ka ma'i, 41% ina ua ma'i na makua elua, a he 14% ina ua loaa i kekahi makua ka mai.Ua hōʻike ʻia nā haʻawina o nā māhoe e pili ana me psoriasis he 72% ka nui o nā māhoe monozygotic e loaʻa i ka maʻi i ka manawa like a ʻo nā māhoe dizygotic he 30% hiki ke loaʻa ka maʻi i ka manawa like. ʻOi aku ma mua o 10 mea i kapa ʻia ʻo susceptibility loci i ʻike ʻia e pili pū ana me ka ulu ʻana o psoriasis.
2. Nā mea palekana
ʻO ka hana maʻamau o T-lymphocytes a me ka infiltration i ka epidermis a i ʻole dermis he mau hiʻohiʻona pathophysiological nui o psoriasis, e hōʻike ana i ke komo ʻana o ka ʻōnaehana pale i ka hoʻomohala ʻana a me ka holomua o ka maʻi.Ua hōʻike ʻia nā haʻawina hou i ka hana ʻana o IL-23 e nā cell dendritic a me nā ʻāpana antigen-presenting cell (APCs) e hoʻoulu i ka ʻokoʻa a me ka hoʻonui ʻana o CD4 + helper T lymphocytes, Th17 cell, a me nā cell Th17 makua ʻokoʻa hiki ke hūnā i nā ʻano mea like ʻole o Th17. e like me IL-17, IL-21, a me IL-22, ka mea e hoʻoulu ai i ka hoʻonui nui ʻana o nā keratin-forming cell a i ʻole ka pane inflammatory o nā cell synovial. No laila, hiki i nā pūnaewele Th17 a me ka axis IL-23 / IL-17 ke hana nui i ka pathogenesis o psoriasis.
3. Kaiapuni a me Metabolic Factors
He kuleana koʻikoʻi nā mea kaiapuni i ka hoʻoulu ʻana a i ʻole ka hoʻonui ʻana i ka psoriasis, a i ʻole i ka hoʻolōʻihi ʻana i ka maʻi, e like me nā maʻi, ke kaumaha o ka noʻonoʻo, nā maʻamau maikaʻi ʻole (e laʻa, ka puhi ʻana, ka waiʻona), ka ʻeha, a me nā hopena i kekahi mau lāʻau.Hoʻopili pinepine ʻia ka hoʻomaka ʻana o ka pitting psoriasis me ka maʻi streptococcal acute o ka pharynx, a hiki i ka lāʻau anti-infection ke alakaʻi i ka hoʻomaikaʻi a me ka hōʻemi ʻana a me ke kala ʻana o nā ʻili ʻili. ʻO ke kaumaha o ka noʻonoʻo (e like me ke koʻikoʻi, nā maʻi hiamoe, ka hana nui) hiki ke hoʻoulu ʻia ka psoriasis, hoʻonui a hoʻi hou paha, a hiki i ka hoʻohana ʻana i ka psychological suggest therapy ke hoʻohaʻahaʻa i ke ʻano. Ua ʻike pū ʻia ʻo ka hypertension, diabetes, hyperlipidemia, coronary artery maʻi a me ka metabolic syndrome ka nui o ka prevalence ma waena o nā maʻi psoriasis.
Ka manawa hoʻouna: Mar-17-2023
