He aha nā kumu o ka psoriasis?

ʻO nā kumu o ka psoriasis e pili ana i nā kumu genetic, immune, environmental a me nā mea ʻē aʻe, a ʻaʻole maopopo loa kona pathogenesis.

 1. Nā kumu hoʻoilina

Ua hōʻike ʻia nā haʻawina he nui he kuleana koʻikoʻi ko nā kumu hoʻoilina i ka pathogenesis o ka psoriasis. ʻO ka mōʻaukala ʻohana o ka maʻi no 10% a 23.8% o nā maʻi ma Kina a ma kahi o 30% ma nā ʻāina ʻē.ʻO ka likelika o ka loaʻa ʻana o kahi keiki me ka psoriasis he 2% inā ʻaʻohe o nā mākua i loaʻa ka maʻi, 41% inā loaʻa ka maʻi i nā mākua ʻelua, a he 14% inā loaʻa ka maʻi i kekahi makua.Ua hōʻike ʻia nā haʻawina o nā māhoe e pili ana i ka psoriasis he 72% ka hiki ke loaʻa i nā māhoe monozygotic i ka maʻi i ka manawa like a he 30% ka hiki ke loaʻa i nā māhoe dizygotic i ka maʻi i ka manawa like. Ua ʻike ʻia ma mua o 10 mau mea i kapa ʻia he susceptibility loci e pili pono ana i ka ulu ʻana o ka psoriasis.

2. Nā kumu pale kino

 ʻO ka hoʻoulu ʻana maʻamau ʻole o nā T-lymphocytes a me ke komo ʻana i loko o ka epidermis a i ʻole dermis he mau hiʻohiʻona pathophysiological koʻikoʻi o ka psoriasis, e hōʻike ana i ke komo ʻana o ka ʻōnaehana pale i ka ulu ʻana a me ka holomua o ka maʻi.Ua hōʻike ʻia nā haʻawina hou e hiki i ka hana ʻana o IL-23 e nā cell dendritic a me nā cell antigen-presenting (APCs) ke hoʻoulu i ka hoʻokaʻawale ʻana a me ka hoʻonui ʻana o nā lymphocytes T kōkua CD4+, nā cell Th17, a me nā cell Th17 makua i hoʻokaʻawale ʻia ke hūnā i nā ʻano mea like me Th17 e like me IL-17, IL-21, a me IL-22, e hoʻoulu ai i ka hoʻonui nui ʻana o nā cell keratin-forming a i ʻole ka pane mumū o nā cell synovial. No laila, hiki i nā cell Th17 a me ke axis IL-23/IL-17 ke pāʻani i kahi kuleana koʻikoʻi i ka pathogenesis o ka psoriasis.

3. Nā Kumu Kaiapuni a me ka Metabolic

He kuleana koʻikoʻi ko nā kumu o ke kaiapuni i ka hoʻoulu ʻana a i ʻole ka hoʻonui ʻana i ka psoriasis, a i ʻole i ka hoʻolōʻihi ʻana i ka maʻi, me nā maʻi, ke kaumaha o ka noʻonoʻo, nā ʻano maikaʻi ʻole (e like me ka puhipaka, ka ʻona ʻona), nā ʻeha, a me nā hopena i kekahi mau lāʻau lapaʻau.ʻO ka hoʻomaka ʻana o ka pitting psoriasis e pili pinepine ʻia me ka maʻi streptococcal koʻikoʻi o ka pharynx, a ʻo ka mālama ʻana i ka maʻi e hiki ke alakaʻi i ka hoʻomaikaʻi ʻana a me ka hōʻemi ʻana a i ʻole ka hoʻomaha ʻana o nā ʻeha ʻili. ʻO ke kaumaha noʻonoʻo (e like me ke kaumaha, nā maʻi hiamoe, ka hana nui) hiki ke hana i ka psoriasis, hoʻonui a hoʻi hou paha, a ʻo ka hoʻohana ʻana i ka psychological suggestion therapy hiki ke hōʻoluʻolu i ke kūlana. Ua ʻike ʻia hoʻi he kiʻekiʻe ka laha ʻana o ka hypertension, ka maʻi diabetes, ka hyperlipidemia, ka maʻi artery coronary a me ka metabolic syndrome i waena o nā poʻe maʻi psoriasis.